The UHBD (University of Houston Dynamics) is a FORTRAN program that can be used in the process of molecular design. UHBD has been used to elucidate the "steering" effect of enzyme substrates to the active site of a target enzyme via their electrostatic potential field and to successfully predict the increase rate constraints for faster versions of a human enzyme that operates with diffusion controlled kinetics (super oxide dismutase). UHBD runs on all UNIX platforms and parallel versions will soon be available for SGI, Intel, and KSR, UHBD is memory intensive so a minimum of 96MB of RAM is suggested.
James Briggs
Chief Scientist University of Houston Department of Chemistry 4800 Calhoun Road Houston, TX 77204-5641 USA 713-743-3315 fax:713-743-2709 jbriggs@uh.edu