The Homology program builds a 3D model of a protein from both its amino acid sequence and the known structures of related proteins. The Homology program provides simultaneous optimization of both structure and sequence homologies for multiple proteins in a 3D graphics environment, based on a method developed by Greer.
The protein models built with Homology can be used in drug design or as starting points for X-ray or NMR structure refinement. Appropriate problems include modeling rerun or HIV protease to known structures of aspartyl proteases modeling TPA to known structures of serine proteases; modeling new or modified immunoglobulins to known structures of the family; and generating starting models for NMR structure determination.
Brenda Pfeiffer
Marketing Specialist BIOSYM Technologies, Inc. 9685 Scranton Road San Diego, CA 92121-3752 USA 619-546-5319 fax:619-597-9777 blp@biosym.com